Our laboratory has a long-standing interest in cardiovascular disease, including atherosclerosis, restenosis, and aneurysm. Our goal is to identify genes and mediators that serve cytoprotective functions in protecting cardiovascular system. In response to arterial wall injury, vascular smooth muscle cells (VSMCs) in the blood vessel wall dedifferentiate, migrate, and proliferate, leading to lesion formation and occlusive vascular disease. Understanding the regulation and function of genes expressed in VSMCs will provide insights into the mechanisms of VSMC-specific expression and phenotypic modulation, and the development of vascular disease.
In response to pathological stress, intrinsic defense mechanisms of the body are critical in protecting tissues from injury. Heme oxygenase-1 (HO-1) is such an inducible stress response protein. By degrading the oxidant heme and generating the antioxidant bilirubin and anti-inflammatory molecule carbon monoxide, HO-1 protects cardiovascular system against pathological stress. In addition, we have identified an unexpected role of HO-1 in stem cell differentiation.
Pluripotent stem cells (PSCs), including embryonic and induced pluripotent stem cells, can self-renew and proliferate indefinitely and differentiate into cells of all three germ layers. Therefore, PSCs are attractive sources for regenerative purposes. We are interested in using PSCs in tissue engineering to develop innovative alternative therapeutic strategy for tissue revascularization and regenerative medicine.
EDUCATION / 學歷
| 1982 – 1988 | Ph.D., Biology, University of Houston,Houston, TX, USA |
| 1978 – 1980 | M.S., Plant Physiology, National Taiwan University, Taipei, Taiwan |
| 1973 – 1977 | B.S., Botany, National Taiwan University,Taipei, Taiwan |
EXPERIENCE / 經歷
| 2017/09 – present | Director, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2016/05 – 2017/08 | Acting Director, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2014/07 – 2016/05 | Deputy Director, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2012/09 – 2014/06 | Acting Director, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2012/01 – present | Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2008 – 2011 | Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2007 – 2008 | Associate Investigator, Cardiovascular and Blood Medical Research Center, National Health Research Institutes, Zhunan, Taiwan |
| 2004 – 2007 | Assistant Professor of Medicine, Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA |
| 2000 – 2004 | Instructor in Medicine, Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA |
| 1995 – 1999 | Research Associate, Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, MA, USA |
| 1991 – 1994 | Research Fellow, Nutrition, Harvard School of Public Health, Boston, MA, USA |
| 1989 – 1991 | Research Fellow, Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, TX, USA |
LAB MEMBER / 研究團隊
| 姓名 | 職稱 | 分機 | |
|---|---|---|---|
| 陳忠煌 | 博士後研究員 | 38308 | lockecch@nhri.edu.tw |
| 蔣偉程 | 博士後研究員 | 38308 | wcjiang@nhri.org.tw |
| 陳倩玫 | 博士後研究員 | 38308 | 060714@nhri.edu.tw |
| 林真宇 | 研究助理 | 38308 | 060131@nhri.edu.tw |
| 賀華慧 | 研究助理 | 38308 | legend8240@nhri.edu.tw |
| 龔珮瑜 | 研究助理 | 38308 | pygung@nhri.edu.tw |
| 王竣彥 | 研究助理 | 38308 | 080602@nhri.edu.tw |
| Candra D Hamdin 禾汀 | 中央博班生 | 38308 | cdh@nhri.edu.tw |
HONOR & AWARDS/ 研究團隊榮譽獎項
| 2022 | PhD student Candra D Hamdin (禾汀) received 2022 The 13th Annual JointLife Science & Technology Research Conference of Taoyuan 4Us Poster Award, Second place |
| 2022 | Postdoctoral Fellow Chung-Huang Chen(陳忠煌) received 2022 NHRI Research Day Excellent Poster Award |
| 2022 | Postdoctoral Fellow Wei-Cheng Jiang(蔣偉程) received 2021 MOST Postdoctoral Researcher Academic Researcher Award |
| 2021 | PhD student Candra D Hamdin (禾汀) received 2021 NHRI-NCU Joint Research Conference Excellent Poster Award, third place |
| 2021 | Postdoctoral Fellow Wei-Cheng Jiang(蔣偉程) received 2021 NHRI Research Day Excellent Poster Award |
| Postdoctoral Fellow Chen-mei Chen(陳倩玫) received 2021 NHRI Research Day Excellent Poster Award | |
| 2020 | Postdoctoral Fellow Chung-Huang Chen(陳忠煌) received 2020 NHRI Research Day Excellent Poster Award |
| Research Assistant Chen-Yu Lin(林真宇) received 2020 NHRI Research Day Excellent RA Award | |
| 2019 | Postdoctoral Fellow Wei-Cheng Jiang(蔣偉程) received 2019 NHRI Research Day Excellent Poster Award |
| 2018 | Postdoctoral Fellow Wei-Cheng Jiang(蔣偉程) received 2018 NHRI Research Day Oral Excellent Paper Award |
PUBLICATIONS / 論文著作
NHRI Institutional Repository國家衛生研究院機構典藏
