This area of research focuses on (1) vascular protection—searching for protective molecules and their mechanisms; (2) inflammation—looking for novel inflammatory and anti-inflammatory factors that are involved in cardiometabolic disorders ; and (3) metabolic dysregulation in human diseases.
Jeng-jiann Chiu, Ph. D. / Distinguished Investigator
Research Field：To elucidate the molecular mechanisms of the regulation of vascular functions, with a special emphasis on the transduction of mechanical stimuli, such as blood flow-induced shear stress and complex flow pattern, into intracellular signaling and the ensuing gene expression and functional responses in cardiovascular disease.
Research Field：Vascular diseases models of atherosclerosis, stenosis, and aneurysm and the underlying molecular mechanisms; phenotypic modulation of vascular smooth muscle cells. Differentiation of embryonic stem cells and induced pluripotent stem cells into vascular cells for vascular repair.
Research Field：Cancer Cell Biology; Cardiovascular Biology; Stem Cell Biology; Signal Transduction; Gene Regulation
- Identification of novel metabolites as therapeutic targets for inflammatory disases
- Cardiovascular Metabolism
- Metabolism in tumor immune microenvironment
Research Field：Immunology, Immunometabolism, Metabolic syndrome, Cancer immunity